method showed that positive rates of TGF-β1 and FN protein declined separately by 64%， 47%， 7% and 82%， 72%， 70%； RT-PCR method showed that mRNA of TGF-β1 and FN declined separately by 72%， 57%， 27%% and 83%， 72%， 68%. Conclusion Multi-target therapeutic effect of HQSJ for RIF may related with decrease of ECM deposition caused by decrease of inflammatory cells， inhibition of TGF-β1 secretion ......